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Caffeine is a central nervous system stimulant commonly found in coffee, tea, and various energy drinks. It is widely used in pharmaceuticals and personal care products for its stimulating effects.…
CAS Number
58-08-2
HS Code
29393000
INCI Name
Caffeine
Molecular Formula
C8H10N4O2
Caffeine is a central nervous system stimulant commonly found in coffee, tea, and various energy drinks. It is widely used in pharmaceuticals and personal care products for its stimulating effects. Caffeine enhances alertness and reduces fatigue, making it a popular ingredient in…
CAS Number
58-08-2
INCI Name
Caffeine
HS Code
29393000
Molecular Formula
C8H10N4O2
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| Property | Specification |
|---|---|
| Appearance | White crystalline powder |
| Odor | Odorless |
| Molecular Weight | 194.19 g/mol |
| Density / Specific Gravity | 1.23 g/cm³ |
| Ph (1% Aqueous Solution) | 6.9 |
| Assay / Purity | 98.5 - 101.0% (on an anhydrous basis) |
| Property | Specification |
|---|---|
| Pka | ~0.6 |
| Ionic Nature | Weakly basic |
| Incompatibilities | Strong oxidizing agents, strong acids, and strong bases. |
| Hazardous Reactions / Decomposition Products | Nitrogen oxides, carbon monoxide, irritating and toxic fumes and gases, carbon dioxide. |
| Property | Specification |
|---|---|
| Melting Point | 235-238 °C |
| Boiling Point | 178 °C at 760 mmHg (sublimes) |
| Flash Point | Not applicable |
| Decomposition Temperature | Decomposes before reaching its boiling point. |
| Thermal Stability | Stable for years under proper storage conditions. Heat above 178°C causes sublimation. |
| Application | Recommended / Max Dosage |
|---|---|
| Stimulant in Beverages | For most healthy adults, up to 400 milligrams (mg) per day is considered safe. This is equivalent to about four 8-ounce cups of brewed coffee. |
| Personal Care Products (Topical) - Under-eye creams and serums | 1-3% |
| Personal Care Products (Topical) - Body / cellulite creams | 1-5% |
| Personal Care Products (Topical) - Face products for puffiness | 1-2% |
| Personal Care Products (Topical) - Hair scalp serums | 0.5-1% |
| Dietary Supplements | Up to 400 mg per day is considered safe for most adults. |
| Food Additive (e.g., Carbonated Beverages) | The FDA has cited that less than 200 ppm (<0.02%) of caffeine is authorized for use in carbonated beverages. |
Caffeine, also known as 1,3,7-Trimethylxanthine, is a widely consumed psychoactive substance with significant applications in various industries. As a central nervous system stimulant, it is primarily used to increase alertness and reduce fatigue. Caffeine manufacturers and suppliers focus on producing high-purity caffeine to meet the stringent demands of the pharmaceutical, food, and personal care industries. The production process is carefully controlled to ensure consistency and stability, which are crucial for the compound's effectiveness in various applications. In the food and beverage industry, caffeine is a key ingredient in energy drinks, coffee, and tea, providing the stimulating effects that consumers seek. In pharmaceuticals, it is used to enhance the efficacy of pain relievers and as a treatment for migraines. The personal care industry utilizes caffeine in skincare products for its antioxidant properties and ability to reduce puffiness. Caffeine suppliers are increasingly adopting sustainable practices to minimize environmental impact, aligning with the growing demand for eco-friendly raw materials. These efforts include optimizing energy use during production and reducing waste emissions. The trend toward sustainable manufacturing practices is particularly important in the global market, where consumers are becoming more environmentally conscious. Caffeine's versatility and effectiveness make it a fundamental compound in modern industry, with applications ranging from food and beverages to pharmaceuticals and personal care products.
Caffeine, also known as 1,3,7-Trimethylxanthine, is a widely consumed psychoactive substance with significant applications in various industries. As a central nervous system stimulant, it is primarily used to increase alertness and reduce fatigue. Caffeine manufacturers and suppliers focus on producing high-purity caffeine to meet the stringent demands of the pharmaceutical, food, and personal care industries. The production process is carefully controlled to ensure consistency and stability, which are crucial for the compound's effectiveness in various applications. In the food and beverage industry, caffeine is a key ingredient in energy drinks, coffee, and tea, providing the stimulating effects that consumers seek. In pharmaceuticals, it is used to enhance the efficacy of pain relievers and as a treatment for migraines. The personal care industry utilizes caffeine in skincare products for its antioxidant properties and ability to reduce puffiness. Caffeine suppliers are increasingly adopting sustainable practices to minimize environmental impact, aligning with the growing demand for eco-friendly raw materials. These efforts include optimizing energy use during production and reducing waste emissions. The trend toward sustainable manufacturing practices is particularly important in the global market, where consumers are becoming more environmentally conscious. Caffeine's versatility and effectiveness make it a fundamental compound in modern industry, with applications ranging from food and beverages to pharmaceuticals and personal care products.
| Region | Max Allowed Level | Notes | Certification Body |
|---|---|---|---|
| United States | 0.02% | Caffeine is listed as Generally Recognized as Safe (GRAS) for use in cola-type beverages up to 0.02%. This GRAS status does not automatically extend to other food categories or dietary supplements. For dietary supplements, it is considered an "old" dietary ingredient and does not require a New Dietary Ingredient (NDI) notification. | FDA registration for food facilities. Subject to the Federal Food, Drug, and Cosmetic Act (FD&C Act). Products must comply with TSCA. |
| European Union | 3% | In cosmetics, caffeine functions as a skin conditioning and masking agent. It is listed in the CosIng database. | REACH registration is required for substances manufactured or imported in quantities of one tonne or more per year. GMP (Good Manufacturing Practices) for pharmaceuticals and cosmetics. |
| Canada | - | Caffeine is listed on the Natural Health Products Ingredients Database. For cosmetics, it must be listed on the label if present. | Site License and Product License for Natural Health Products. |
| India | - | Caffeine is regulated under the Food Safety and Standards Authority of India (FSSAI) for use in food products. | FSSAI license for food products. |
| Japan | - | Regulated under the Pharmaceutical and Medical Device Act (PMD Act) and the Act on Securing Quality, Efficacy and Safety of Products Including Pharmaceuticals and Medical Devices. | Must comply with standards set by the Ministry of Health, Labour and Welfare (MHLW). |
| Australia | - | Regulated by the Australian Industrial Chemicals Introduction Scheme (AICIS) and the Therapeutic Goods Administration (TGA) for therapeutic goods. | AICIS registration for industrial chemicals. |
| China | - | Caffeine is listed in the Inventory of Existing Cosmetic Ingredients in China (IECIC). | Registration or notification with the National Medical Products Administration (NMPA) for cosmetics. |
| Korea, Republic of | - | Regulated by the Ministry of Food and Drug Safety (MFDS). | Must comply with MFDS regulations for food and cosmetics. |
| ASEAN | - | Regulated under the ASEAN Cosmetic Directive, which harmonizes cosmetic regulations among member states. | Product notification with the respective national regulatory authority. |
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